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360,361 Third, long-term use of SSRIs can increase 5-HT transmission in the LC, 362 thereby increasing the release of GABA to exert inhibitory effects on NA neurons

10.1016/j.cej.2020.125045 115 LiM.YangZ.ChenS.LiuZ.TongL.ZhengS.et al (2023a)

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Therefore, more selective SLC7A11 inhibitors and genetic targeting strategies, including small interfering RNAs (siRNA) and small guide RNAs (sgRNA), would be ideal for clinical purposes

Consistency matters more than perfectionoccasional missed doses dont negate long-term metabolic adaptation